Products for Research Use Only
RegisterLogin

Istradefylline

CAT: 0804-HY-10888-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-10888-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist with Ki of 2.2 nM in experimental models of Parkinson's disease.
CAS Number
155270-99-8
Product Name Alternative
KW-6002
UNSPSC
12352005
Hazard Statement
H301
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Istradefylline.html
Purity
99.89
Solubility
DMSO : 25.33 mg/mL (ultrasonic; warming)
Smiles
O=C1C2=C(N=C(/C=C/C3=CC(OC)=C(OC)C=C3)N2C)N(CC)C(N1CC)=O
Molecular Formula
C20H24N4O4
Molecular Weight
384.43
Precautions
H301
References & Citations
[1]Chen JF, et al. Neuroprotection by caffeine and A (2A) adenosine receptor inactivation in a model of Parkinson's disease. J Neurosci. 2001 May 15;21 (10) :RC143.|[2]Shiozaki S, et al. Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP. Psychopharmacology (Berl) . 1999 Nov;147 (1) :90-5.|[3]Kanda T, et al. Combined use of the adenosine A (2A) antagonist KW-6002 with L-DOPA or with selective D1 or D2 dopamine agonists increases antiparkinsonian activity but not dyskinesia in MPTP-treated monkeys. Exp Neurol. 2000 Apr;162 (2) :321-7.|[4]Brambilla R, et al. Blockade of A2A adenosine receptors prevents basic fibroblast growth factor-induced reactive astrogliosis in rat striatal primary astrocytes. Glia. 2003 Aug;43 (2) :190-4.|[5]Mihara T, et al. Pharmacological characterization of a novel, potent adenosine A1 and A2A receptor dual antagonist, 5-[5-amino-3- (4-fluorophenyl) pyrazin-2-yl]-1-isopropylpyridine-2 (1H) -one (ASP5854), in models of Parkinson's disease and cognition. J Pharm
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

Alternative Products

CatalogName
T6552-01Istradefylline

Popular Products