Simazine

• Description :

  Simazine is a triazine herbicide. Simazine is widely used in agriculture, potted plant and tree production. In addition, Simazine can induce the apoptosis of immune cells in the spleen of mice and inhibit the proliferation of B cells and T cells in mice[1][2][3].

• CAS Number :

  [122-34-9]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H351, H400, H410

• Target :

  Apoptosis; Bcl-2 Family; Caspase; Herbicide; Reactive Oxygen Species (ROS)

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/simazine.html

• Purity :

  99.72

• Solubility :

  DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  CCNC1=NC(Cl)=NC(NCC)=N1

• Molecular Formula :

  C7H12ClN5

• Molecular Weight :

  201.66

• Precautions :

  H302, H351, H400, H410

• References & Citations :

  [1]Morten T Strandberg, et al. Field Effects of Simazine at Lower Trophic Levels--A Review. ci Total Environ. 2002 Sep 16;296 (1-3) :117-37.|[2]Ren R, et al. Oral exposure to the herbicide simazine induces mouse spleen immunotoxicity and immune cell apoptosis. Toxicol Pathol. 2013 Jan;41 (1) :63-72.|[3]Shang JZ, et al. Simazine perturbs the maturational competency of mouse oocyte through inducing oxidative stress and DNA damage. Ecotoxicol Environ Saf. 2022 Jan 15;230:113105.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported