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DHICA

CAT: 0804-HY-W018158-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W018158-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DHICA (5,6-Dihydroxyindole-2-carboxylic acid) is an intermediate in melanin synthesis and a component of true black pigment, and it’s also a moderately potent GPR35 agonist. DHICA shows an ability to stimulate β-arrestin translocation signaling with an EC50 value of 23.2 μM in the U2OS cell line. DHICA plays a significant role in promoting and protecting against DNA damage[1][2].
CAS Number
4790-08-3
Product Name Alternative
5,6-Dihydroxyindole-2-carboxylic acid
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Arrestin; Endogenous Metabolite; GPR35
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/dhica.html
Purity
97.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC(C1=CC2=C(C=C(C(O)=C2)O)N1)=O
Molecular Formula
C9H7NO4
Molecular Weight
193.16
Precautions
H302, H315, H319, H335
References & Citations
[1]Huayun Deng, et al. Synthesis and Agonistic Activity at the GPR35 of 5,6-Dihydroxyindole-2-carboxylic Acid Analogues. ACS Med Chem Lett. 2012 Jun 6;3 (7) :550-4.|[2]Maria Carolina Pellosi, et al. Effects of the melanin precursor 5,6-dihydroxy-indole-2-carboxylic acid (DHICA) on DNA damage and repair in the presence of reactive oxygen species. Arch Biochem Biophys. 2014 Sep 1:557:55-64.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

Alternative Products

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OR1007070DHICA
RC-15139-01Recombinant DHICA Oxidase Antibody
E2R382326DHICA Oxidase Rabbit mAb
MA2270-.1Anti-DHICA Oxidase Rabbit Monoclonal Antibody
GTR18852121Mouse 5,6-dihydroxyindole-2-carboxylic acid oxidase, DHICA oxidase ELISA Kit
MBS9428879-01Mouse 5, 6-dihydroxyindole-2-carboxylic acid oxidase, DHICA oxidase ELISA Kit
134963TYRP1 (Tyrosinase-related Protein 1, TRP1, TRP-1, TRP, TYRP, TYRRP, 5,6-dihydroxyindole-2-carboxylic Acid Oxidase, DHICA Oxidase, Catalase B, CATB, CAS2, Glycoprotein 75, GP75, Melanoma Antigen gp75)
134963-APCTYRP1 (Tyrosinase-related Protein 1, TRP1, TRP-1, TRP, TYRP, TYRRP, 5,6-dihydroxyindole-2-carboxylic Acid Oxidase, DHICA Oxidase, Catalase B, CATB, CAS2, Glycoprotein 75, GP75, Melanoma Antigen gp75) (APC)
MBS6397778-01TYRP1 (Tyrosinase-related Protein 1, TRP1, TRP-1, TRP, TYRP, TYRRP, 5,6-dihydroxyindole-2-carboxylic Acid Oxidase, DHICA Oxidase, Catalase B, CATB, CAS2, Glycoprotein 75, GP75, Melanoma Antigen gp75) (Biotin)
MBS6397776-01TYRP1 (Tyrosinase-related Protein 1, TRP1, TRP-1, TRP, TYRP, TYRRP, 5,6-dihydroxyindole-2-carboxylic Acid Oxidase, DHICA Oxidase, Catalase B, CATB, CAS2, Glycoprotein 75, GP75, Melanoma Antigen gp75) (AP)

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