XP-524

• Description :

  XP-524 is a potent BET and EP300 inhibitor. XP-524 shows great tumoricidal activity in vivo. XP-524 prevents KRAS-induced, neoplastic transformation in vivo and extends survival in two transgenic mouse models of aggressive PDAC. XP-524 also enhances the presentation of self-peptide and tumor recruitment of cytotoxic T lymphocytes. XP-524 has the potential for the research of pancreatic ductal adenocarcinoma (PDAC) [1].

• UNSPSC :

  12352005

• Target :

  Epigenetic Reader Domain

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/xp-524.html

• Purity :

  98.02

• Solubility :

  DMSO : 33.33 mg/mL (ultrasonic)

• Smiles :

  O=C1NC=CC2=C1N(C)C=C2C3=CC4=C(C=CN4C(C5=NC=CC=C5)(C)C6=NC=CC=C6)C(NS(=O)(CC)=O)=C3

• Molecular Formula :

  C30H28N6O3S

• Molecular Weight :

  552.65

• References & Citations :

  [1]Principe DR, et al. XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer. Proc Natl Acad Sci U S A. 2022 Jan 25;119 (4) :e2116764119.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2344825-52-9]