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ST80

CAT: 0804-HY-161774Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161774Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ST80 is an inhibitor for interaction of OTUD4 and CD73. ST80 decreases CD73 protein level, increases CD73 protein turnover, reduces immune evasion of tumor cells, and thus exhibits antitumor efficacy against immunosuppressive triple-negative breast cancer (TNBC) [1].
CAS Number
3080717-78-5
UNSPSC
12352005
Target
CD73
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/st80.html
Smiles
O=C1N(C2=NN([C@@H](C3=CC=C(F)C=C3)C[C@@H](C4=CC=C(C)C=C4)N5)C5=N2)C([C@@]6([H])CC=CC[C@]61[H])=O
Molecular Formula
C26H24FN5O2
Molecular Weight
457.50
References & Citations
[1]Marchese E, et al., Posttranslational protein modifications as gatekeepers of cancer immunogenicity. J Clin Invest. 2024 May 15;134 (10) :e180914.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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