RegisterLogin

E6446

CAT: 0804-HY-12756-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12756-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
E6446 is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 also improves liver pathology in high-fat diet (HFD) -fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD) [1][2][3].
CAS Number
[1219925-73-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Stearoyl-CoA Desaturase (SCD) ; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/e6446.html
Concentration
10mM
Purity
98.78
Solubility
DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C1(C2=CC=C(OCCCN3CCCC3)C=C2)=NC4=CC=C(OCCCN5CCCC5)C=C4O1
Molecular Formula
C27H35N3O3
Molecular Weight
449.59
Precautions
H302, H315, H319, H335
References & Citations
[1]Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85 (3) :429-40.|[2]Franklin BS, et al. Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria. Proc Natl Acad Sci U S A. 2011 Mar 1;108 (9) :3689-94.|[3]Wang W, et al. Identification of novel SCD1 inhibitor alleviates nonalcoholic fatty liver disease: critical role of liver-adipose axis. Cell Commun Signal. 2023 Sep 30;21 (1) :268.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR7; TLR9
Citation 01
Cell Rep. 2025 Jun 13;44 (6) :115851.|Infect Immun. 2019 Dec 17;88 (1) :e00697-19.|J Virol. 2025 Jun 12:e0069025.|Oxid Med Cell Longev. 2019 Apr 28:2019:6527638.|SSRN. 2025 Sep 10.|Cell Commun Signal. 2023 Sep 30;21 (1) :268.|Patent. US20210388060A1.|Research Square Preprint. 2021 Mar.|Vet Microbiol. 2017 Aug:207:56-62.

Related Products

CatalogName

Alternative Products

CatalogName
MBS3847036-01E6446
MBS3607244-01E6446 dihydrochloride
A22520-5E6446 5mg
MBS131210-01E6446 HCl
A22520-10E6446 10mg
A22520-25E6446 25mg
A22520-50E6446 50mg
A22520-1E6446 1mg
A22520-100E6446 100mg
A17149-2E6446 dihydrochloride 2mg

Popular Products