Eudebeiolide B

• Description :

  Eudebeiolide B is a compound that can be isolated from Salvia plebeia R. Br. Eudebeiolide B inhibits osteoclastogenesis by regulating RANKL-induced NF-κB, c-Fos and calcium signaling. Eudebeiolide B can be used for osteoclast-related diseases research[1].

• Product Name Alternative :

  Plebeiolide D

• UNSPSC :

  12352005

• Target :

  Akt; NF-κB; Nuclear Factor of activated T Cells (NFAT) ; Phosphatase

• Type :

  Natural Products

• Related Pathways :

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/eudebeiolide-b.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O[C@]12C(C[C@@]3([H])[C@](C1)(C=CC([C@@H]3C)=O)C)=C(C(O2)=O)C

• Molecular Formula :

  C15H18O4

• Molecular Weight :

  262.30

• References & Citations :

  [1]Kim MH, et.al. Eudebeiolide B Inhibits Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss by Regulating RANKL-Induced NF-κB, c-Fos and Calcium Signaling. Pharmaceuticals (Basel) . 2020 Dec 16;13 (12) :468.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Akt; NF-κB

• CAS Number :

  [1934299-51-0]