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NSC636819

CAT: 0804-HY-110154-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-110154-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NSC636819 is a competitive and selective inhibitor of KDM4A/KDM4B. KDM4A/KDM4B are potential progression factors for prostate cancer. NSC636819 has the potential for the research of cancer diseases, especially prostate cancer[1][2].
CAS Number
1618672-71-1
UNSPSC
12352005
Target
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc636819.html
Purity
98.90
Solubility
DMSO : 5.1015 mg/mL (ultrasonic; warming)
Smiles
ClC1=C(Cl)C=CC(/C=C/C2=C([N+]([O-])=O)C=C([N+]([O-])=O)C(/C=C/C3=CC(Cl)=C(Cl)C=C3)=C2)=C1
Molecular Formula
C22H12Cl4N2O4
Molecular Weight
510.15
References & Citations
[1]Chu CH, et al. KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. J Med Chem. 2014;57 (14) :5975-5985.|[2]Wang J, et al. Silencing the epigenetic silencer KDM4A for TRAIL and DR5 simultaneous induction and antitumor therapy. Cell Death Differ. 2016 Nov 1;23 (11) :1886-1896.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM4

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CatalogName
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CatalogName
BA4803-5NSC636819
bs-60290C-01NSC636819, KDM4A/KDM4B Inhibitor

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