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Bucladesine

CAT: 0804-HY-B0764BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B0764BSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bucladesine (DBcAMP) is a membrane permeable selective activator that activates cyclic adenosine phosphate dependent protein kinase A (PKA) . The main regulatory mechanism of Bucladesine involves the cAMP/PKA signaling pathway. When Bucladesine activates PKA, it can promote a variety of cellular processes, including neurodevelopment, growth and plasticity. In particular, the cAMP/PKA signaling pathway plays a key role in the expression of long-term enhancement (LTP) and long-term inhibition (LTD), as well as in the formation of long-term memory in the hippocampus. Bucladesine can be used to study memory formation and neuroplasticity[1].
CAS Number
362-74-3
Product Name Alternative
Dibutyryl cAMP; DBcAMP
UNSPSC
12352005
Hazard Statement
H315-H319
Target
PKA
Type
Reference compound
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bucladesine.html
Solubility
10 mM in DMSO
Smiles
O=C(CCC)O[C@H]1[C@H](N2C(N=CN=C3NC(CCC)=O)=C3N=C2)O[C@@](CO4)([H])[C@@]1([H])OP4(O)=O
Molecular Formula
C18H24N5O8P
Molecular Weight
469.39
Precautions
P264-P280-P302+P352-P362+P364
References & Citations
[1]Sharifzadeh M, et al. Post-training intrahippocampal infusion of nicotine–bucladesine combination causes a synergistic enhancement effect on spatial memory retention in rats[J]. European journal of pharmacology, 2007, 562 (3) : 212-220.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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