Meropenem (trihydrate)

Meropenem (trihydrate)

• CAS Number: 119478-56-7
• UNSPSC Description: Meropenem trihydrate (SM 7338 trihydrate) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem trihydrate has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL)[1][2].
• Target Antigen: Antibiotic; Bacterial; Penicillin-binding protein (PBP)
• Type: Reference compound
• Related Pathways: Anti-infection
• Field of Research: Infection; Cancer
• Assay Protocol: https://www.medchemexpress.com/meropenem-trihydrate.html
• Smiles: O=C(C(N12)=C(S[C@@H]3CN[C@H](C(N(C)C)=O)C3)[C@H](C)[C@]2([H])[C@@H]([C@H](O)C)C1=O)O.O.O.O
• Molecular Weight: 437.51
• References & Citations: [1]L Slaney, et al. In-vitro activity of meropenem against Neisseria gonorrhoeae, Haemophilus influenzae and H. ducreyi from Canada and Kenya. J Antimicrob Chemother. 1989 Sep;24 Suppl A:183-6.|[2]George G Zhanel, et al. Comparative review of the carbapenems. Drugs. 2007;67(7):1027-52.|[3]Umit Ateskan, et al. Deferoxamine and meropenem combination therapy in experimental acute pancreatitis. Pancreas. 2003 Oct;27(3):247-52.Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00414-18. |bioRxiv. 2024 May 10.|Int J Antimicrob Agents. 2018 Aug;52(2):269-271.|Biomed Pharmacother. 2023 Nov 8:115856.|Emerg Microbes Infect. 2024 Dec;13(1):2321981.|Infect Drug Resist. 2021 Jun 30;14:2499-2507.|J Antimicrob Chemother. 2020 Jul 1;75(7):1850-1858.|Microbiol Spectr. 2024 Aug 6;12(8):e0397923.|Microorganisms. 2024 Mar 13, 12(3), 575.|Nano Today. 2024 Dec.|Nat Commun. 2022 Mar 2;13(1):1116.|Nat Microbiol. 2023 Mar;8(3):410-423.|Open Forum Infect Dis. 2023 Jan 27.|Proc Natl Acad Sci U S A. 2024 Jan 16;121(3):e2314514121.|Spectrochim Acta A Mol Biomol Spectrosc. 2020 Apr 5;230:118066.
• Shipping Conditions: Room Temperature