Gemcabene

CAT: 0804-HY-109567-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-109567-02Size:10 mM - 1 mL

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

Gemcabene (PD-72953), a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) and lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), exerting anti-inflammatory activity[1][2][3].

CAS Number

183293-82-5

Product Name Alternative

PD-72953

UNSPSC

12352211

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/gemcabene.html

Purity

99.91

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)C(C)(C)CCCCOCCCCC(C)(C)C(O)=O

Molecular Formula

C16H30O5

Molecular Weight

302.41

References & Citations

[1]Mandema JW, et al. Model-based development of gemcabene, a new lipid-altering agent. AAPS J. 2005 Oct 7;7 (3) :E513-22.|[2]Srivastava RAK, et al. Gemcabene, a First-in-Class Hypolipidemic Small Molecule in Clinical Development, Attenuates Osteoarthritis and Pain in Animal Models of Arthritis and Pain. Front Pharmacol. 2018 May 11;9:471.|[3]Oniciu DC, et al. Gemcabene downregulates inflammatory, lipid-altering and cell-signaling genes in the STAM™ model of NASH. PLoS One. 2018 May 30;13 (5) :e0194568.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Chemical Information

Gemcabene

Gemcabene is a new drug that lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C).

CAS Number	183293-82-5
PubChem CID	157692
IUPAC Name	6-(5-carboxy-5-methylhexoxy)-2,2-dimethylhexanoic acid
Molecular Formula	C16H30O5
Molecular Weight	302.41
XLogP	3.1
Topological Polar Surface Area	83.8
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	12
Heavy Atom Count	21
Formal Charge	0
Complexity	302

SMILES

CC(C)(CCCCOCCCCC(C)(C)C(=O)O)C(=O)O

InChI

InChI=1S/C16H30O5/c1-15(2,13(17)18)9-5-7-11-21-12-8-6-10-16(3,4)14(19)20/h5-12H2,1-4H3,(H,17,18)(H,19,20)

InChIKey

SDMBRCRVFFHJKR-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 183293-82-5

CID: 157692

Formula: C16H30O5

MW: 302.41

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	302.41
XLogP3	3.1
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	12
Exact Mass	302.20932405
Monoisotopic Mass	302.20932405
Topological Polar Surface Area	83.8 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	302
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
MBS3602827-01	Gemcabene
MBS3845851-01	Gemcabene calcium
A20083-5	Gemcabene 5mg
A20083-2	Gemcabene 2mg
A20083-100	Gemcabene 100mg
GTR19268414-01	Gemcabene-CoA
A20083-10	Gemcabene 10mg
A20083-50	Gemcabene 50mg
A20083-25	Gemcabene 25mg
A21421-25	Gemcabene calcium 25mg

Gemcabene

Chemical Information

Alternative Products

Popular Products