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Hydrastine

CAT: 0804-HY-B0927-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0927-01Size:1 mg
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Description
Hydrastine ((-) -β-Hydrastine; (1R,9S) -β-Hydrastine) is a selective competitive inhibitor of tyrosine hydroxylase (TH), inhibiting dopamine biosynthesis (IC50=20.7 μM, PC12 cells) . Hydrastine also inhibits the organic cation transporter OCT1 (IC50=6.6 μM) . Hydrastine may cause neuronal toxicity through mitochondrial dysfunction rather than oxidative stress damage, and can aggravate cell apoptosis when combined with L-DOPA. Hydrastine can be used to study Parkinson's disease-related dopaminergic neuronal damage[1][2].
CAS Number
118-08-1
Product Name Alternative
(-) -β-Hydrastine; (1R,9S) -β-Hydrastine
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Dopamine Receptor; OAT; Tyrosine Hydroxylase
Type
Natural Products
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Hydrastine.html
Concentration
10mM
Purity
99.57
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1O[C@H]([C@@H]2N(C)CCC3=C2C=C(OCO4)C4=C3)C5=C1C(OC)=C(OC)C=C5
Molecular Formula
C21H21NO6
Molecular Weight
383.39
Precautions
H302, H312, H332
References & Citations
[1]Yin SY, et al. Effects of (1R,9S) -beta-hydrastine on l-DOPA-induced cytotoxicity in PC12 cells. Eur J Pharmacol. 2004 Mar 19;488 (1-3) :71-7.|[2]Oyanna VO, et al. Goldenseal-Mediated Inhibition of Intestinal Uptake Transporters Decreases Metformin Systemic Exposure in Mice. Drug Metab Dispos. 2023 Nov;51 (11) :1483-1489.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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