Products for Research Use Only
RegisterLogin

EMD386088

CAT: 0804-HY-103130-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-103130-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
EMD386088 is a potent and selective 5-HT6 receptor (5-HT6R) agonist with an EC50 of 1.0 nM. EMD-386088 is inactive against other HT receptors except 5-HT3R (IC50 of 34 nM) . EMD386088 regulates the activity of ERK1/2. EMD386088 has the potential for the research of alzheimer's disease (AD) and schizophrenia[1][2][3][4].
CAS Number
1171123-46-8
UNSPSC
12352005
Hazard Statement
H301
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/emd386088.html
Purity
99.06
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(N1)=C(C2=CCNCC2)C3=C1C=CC(Cl)=C3.[H]Cl
Molecular Formula
C14H16Cl2N2
Molecular Weight
283.20
Precautions
H301
References & Citations
[1]Yun HM, et al. 5-HT6 receptor ligands, EMD386088 and SB258585, differentially regulate 5-HT6 receptor-independent events. Toxicol In Vitro. 2011 Dec;25 (8) :2035-40.|[2]Meneses A, et al. The effects of the 5-HT (6) receptor agonist EMD and the 5-HT (7) receptor agonist AS19 on memory formation. Behav Brain Res. 2008 Dec 16;195 (1) :112-9. |[3]Amodeo DA, et al. 5-HT6 receptor agonist EMD386088 impairs behavioral flexibility and working memory. Behav Brain Res. 2018 Sep 3;349:8-15.|[4]Mattsson C, et al. 2-Alkyl-3- (1,2,3,6-tetrahydropyridin-4-yl) -1H-indoles as novel 5-HT6 receptor agonists. Bioorg Med Chem Lett. 2005 Oct 1;15 (19) :4230-4.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT6 Receptor; MUC2

Alternative Products

CatalogName
WWB12346-01EMD386088

Popular Products