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Abrocitinib

CAT: 0804-HY-107429-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107429-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Abrocitinib (PF-04965842) is a potent, orally active and selective JAK1 inhibitor, with IC50s of 29 and 803 nM for JAK1 and JAK2, respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 (IC50, 1.253 μM), and inhibits phosphorylation of STAT1, STAT3 and STAT5 after stimulation. Effective in autoimmune disease[1].
CAS Number
1622902-68-4
Product Name Alternative
PF-04965842
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Abrocitinib.html
Purity
99.26
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN([C@H]1C[C@@H](NS(CCC)(=O)=O)C1)C2=C3C(NC=C3)=NC=N2
Molecular Formula
C14H21N5O2S
Molecular Weight
323.41
Precautions
H302, H315, H319, H335
References & Citations
[1]Vazquez ML, et al. Identification of N-{cis-3-[Methyl (7H-pyrrolo[2,3-d]pyrimidin-4-yl) amino]cyclobutyl}propane-1-sulfonamide (PF-04965842) : A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases. J Med Chem. 2018 Feb 8;61 (3) :1130-1152.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
JAK1; JAK2; Tyk2

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