Vasicine

• Description :

  Vasicine (peganine) is a quinazoline alkaloid isolated from Justicia adhatoda. Vasicine activates PI3K/Akt signaling pathway, exhibits antioxidant, anti-inflammatory and antibacterial activities[1][2][3].

• Product Name Alternative :

  Peganine

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Akt; Bacterial; PI3K

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; PI3K/Akt/mTOR

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/vasicine.html

• Purity :

  98.0

• Solubility :

  DMSO : 83.33 mg/mL (ultrasonic)

• Smiles :

  O[C@H]1CCN2C1=NC3=C(C=CC=C3)C2

• Molecular Formula :

  C11H12N2O

• Molecular Weight :

  188.23

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Grange JM, et al. Activity of bromhexine and ambroxol, semi-synthetic derivatives of vasicine from the Indian shrub Adhatoda vasica, against Mycobacterium tuberculosis in vitro. J Ethnopharmacol. 1996 Jan;50 (1) :49-53.|[2]Jiang T, et al., Protective Effect Of Vasicine Against Myocardial Infarction In Rats Via Modulation Of Oxidative Stress, Inflammation, And The PI3K/Akt Pathway. Drug Des Devel Ther. 2019 Oct 31;13:3773-3784.|[3]Singh VK, et al., Anti-secretory and cyto-protective effects of peganine hydrochloride isolated from the seeds of Peganum harmala on gastric ulcers. Phytomedicine. 2013 Oct 15;20 (13) :1180-5.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [6159-55-3]