PP487

CAT: 0804-HY-15268Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-15268Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

PP487 is a dual inhibitor of tyrosine kinase/PI (3) Ks with IC50 values of 0.017 μM, 0.072 μM, 0.004 μM, 0.01 μM, 0.55 μM, 0.22 μM, and DNA-PK, mTOR, Hck, Src, EGFR, EphB4, and PDGFR, respectively. PP487 can be used for cancer research[1].

CAS Number

1092787-12-6

UNSPSC

12352005

Target

Bcr-Abl; c-Met/HGFR; DNA-PK; EGFR; mTOR; PDGFR; PI3K; Src; VEGFR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; JAK/STAT Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pp487.html

Solubility

10 mM in DMSO

Smiles

BrC1=C(O)C=C(C2=NN(C(C)C)C3=C2C(N)=NC=N3)C=C1

Molecular Formula

C14H14BrN5O

Molecular Weight

348.20

References & Citations

[1]Apsel B, et al. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4 (11) :691-9.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Abl; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ; VEGFR2/KDR/Flk-1

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