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Naphthazarin

CAT: 0804-HY-N7526-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N7526-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Naphthazarin (DHNQ) is a microtubule depolymerizing agent. Naphthazarin can improve motor function and reduce neuroinflammation in mouse models of Parkinson's disease. Naphthazarin can induce tumor cell apoptosis, autophagy, and cell cycle arrest. Naphthazarin can also induce erythrocyte apoptosis. Naphthazarin can be used in the research of tumors and neurodegenerative diseases[1][2][3].
CAS Number
475-38-7
Product Name Alternative
DHNQ; 5,8-Dihydroxy-1,4-naphthoquinone
UNSPSC
12352005
Hazard Statement
H302+H312+H332, H315, H319
Target
Akt; Apoptosis; Autophagy; PI3K
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; PI3K/Akt/mTOR
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/naphthazarin.html
Purity
99.59
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
O=C1C=CC(C2=C1C(O)=CC=C2O)=O
Molecular Formula
C10H6O4
Molecular Weight
190.15
Precautions
H302+H312+H332, H315, H319
References & Citations
[1]Seon Young Choi, et al. Naphthazarin has a protective effect on the 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced Parkinson's disease model. J Neurosci Res. 2012 Sep;90 (9) :1842-9.|[2]Omar Aljanadi, et al. Stimulation of Suicidal Erythrocyte Death by Naphthazarin. Basic Clin Pharmacol Toxicol. 2015 Dec;117 (6) :369-74.|[3]Acharya BR, et al. The microtubule depolymerizing agent naphthazarin induces both apoptosis and autophagy in A549 lung cancer cells. Apoptosis. 2011 Sep;16 (9) :924-39. doi: 10.1007/s10495-011-0613-1
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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