TLR4 rabbit pAb

TLR4 rabbit pAb

• Description: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
• Synonyms: TLR4; Toll-like receptor 4; hToll; CD284
• Gene ID: 7099
• UniProt: O00206
• Cellular Locus: Cell membrane ; Single-pass type I membrane protein. Early endosome. Cell projection, ruffle. Upon complex formation with CD36 and TLR6, internalized through dynamin-dependent endocytosis (PubMed:20037584). Colocalizes with RFTN1 at cell membrane and then together with RFTN1 moves to endosomes, upon lipopolysaccharide stimulation..
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant Protein of TLR4
• Clonality: Polyclonal
• Validated Applications: IHC, IF
• Stability: 1 year
• Dilution: IHC: 1:200-500
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.