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Difamilast (Standard)

CAT: 0804-HY-109085R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-109085R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Difamilast (Standard) is the analytical standard of Difamilast. This product is intended for research and analytical applications. Difamilast (OPA-15406) is a topical, selective and nonsteroidal phosphodiesterase-4 (PDE4) inhibitor with particularly efficient inhibition of subtype B (IC50=11.2 nM) . Difamilast can be used for the research of mild to moderate atopic dermatitis (AD) [1][2][3].
CAS Number
937782-05-3
Product Name Alternative
OPA-15406 (Standard)
UNSPSC
12352005
Target
Phosphodiesterase (PDE) ; Reference Standards
Type
Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/difamilast-standard.html
Smiles
CC(C)OC(C=C(C1=NC(CNC(C(C=CC=C2)=C2OCC)=O)=CO1)C=C3)=C3OC(F)F
Molecular Formula
C23H24F2N2O5
Molecular Weight
446.44
References & Citations
[1]Hanifin JM, et, al. OPA-15406, a novel, topical, nonsteroidal, selective phosphodiesterase-4 (PDE4) inhibitor, in the treatment of adult and adolescent patients with mild to moderate atopic dermatitis (AD) : A phase-II randomized, double-blind, placebo-controlled study. J Am Acad Dermatol. 2016 Aug;75 (2) :297-305.|[2]Ahluwalia J, et, al. Phosphodiesterase 4 Inhibitor Therapies for Atopic Dermatitis: Progress and Outlook. Drugs. 2017 Sep;77 (13) :1389-1397.|[3]Soeberdt M, et, al. Small molecule drugs for the treatment of pruritus in patients with atopic dermatitis. Eur J Pharmacol. 2020 Aug 15;881:173242.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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