Promethazine-d4

CAT: 0804-HY-B1296S1Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B1296S1Size:1 mg
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Description
Promethazine-d4 is a deuterated-labeled promethazine (HY-B0781) . Promethazine is an orally active H1 receptor and mAChR antagonist with antihistamine (H1), sedative, antiemetic, anticholinergic, and anti-motion sickness properties[1][2][3][4][5][6][7].
CAS Number
[1173147-64-2]
Product Name Alternative
(±) -Promethazine-d4; N, N-dimethyl-1-phenothiazin-10-yl-propan-2-amine-d4
UNSPSC
12352005
Target
Adrenergic Receptor; Histamine Receptor; Isotope-Labeled Compounds; mAChR
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
[2H]C1=CC2=C(N(C3=C(S2)C=C(C=C3[2H])[2H])CC(N(C)C)C)C([2H])=C1
Molecular Formula
C17H16D4N2S
Molecular Weight
288.44
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Burt DR, et al. Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain. Science. 1977 Apr 15;196 (4287) :326-8.|[3]Strenkoski-Nix LC, et al. Pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories and oral syrup to healthy subjects. Am J Health Syst Pharm. 2000 Aug 15;57 (16) :1499-505.|[4]Fiorella D, et al. The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. I: Antagonist correlation analysis. Psychopharmacology (Berl) . 1995 Oct;121 (3) :347-56.|[5]Seeman P, et al. Dopamine D2 receptor binding sites for agonists. A tetrahedral model. Mol Pharmacol. 1985 Nov;28 (5) :391-9.|[6]Xinyue Tan, et al. Promethazine inhibits proliferation and promotes apoptosis in colorectal cancer cells by suppressing the PI3K/AKT pathway. Biomed Pharmacother. 2021 Nov;143:112174.|[7]Niloofar Amidi, et al. A Behavioral Study of Promethazine Interaction with Analgesic Effect of Diclofenac: Pain Combination Therapy. J Pharmacopuncture. 2020 Mar 31;23 (1) :18-24.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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