Ionomycin

• UNSPSC Description:

  Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC)[1][2][3].

• Target Antigen:

  Antibiotic; Apoptosis; Bacterial; Calcium Channel; PKC

• Type:

  Natural Products

• Related Pathways:

  Anti-infection;Apoptosis;Epigenetics;Membrane Transporter/Ion Channel;Neuronal Signaling;TGF-beta/Smad

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/Ionomycin.html

• Smiles:

  O=C(O)CC[C@@H](C)C[C@H](C)C[C@H](C)C(/C=C(O)/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@]([C@@H]2O[C@](C)([C@H](O)C)CC2)(C)O1)=O

• Molecular Weight:

  709.01

• References & Citations:

  [1]Liu C,et al. Characterization of ionomycin as a calcium ionophore. J Biol Chem. 1978 Sep 10;253(17):5892-4.|[2]Chatila T, et al. Mechanisms of T cell activation by the calcium ionophore ionomycin. J Immunol. 1989 Aug 15;143(4):1283-9.|[3]Gil-Parrado S, et al. Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members. J Biol Chem. 2002 Jul 26;277(30):27217-26.|[4]Stoeck A, et al A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44. Biochem J. 2006 Feb 1;393(Pt 3):609-18.|[5]Junsuke Uwada, et al. Store-operated calcium entry (SOCE) contributes to phosphorylation of p38 MAPK and suppression of TNF-α signalling in the intestinal epithelial cells. Cell Signal. 2019 Nov;63:109358.ACS Infect Dis. 2023 Mar 14.|Acta Pharm Sin B. 2024 Jun 20.|Acta Pharmacol Sin. 2022 Sep 23.|Adv Sci (Weinh). 2023 Jan 15;e2203869.|Adv Sci (Weinh). 2024 Mar 14:e2306378.|Adv Sci (Weinh). 2024 May 5:e2400297.|Aging. 2019 Aug 19;11(16):6490-6502.|Aging. 2021 Jun 2;13(11):15638-15658.|Aging. 2021 Mar 24;13(7):10312-10325.|Arch Oral Biol. 2024 Jul 3:166:106043.|Biochem Pharmacol. 2023 Dec 2:115957.|Biomed Pharmacother. 2022 Jan 17;147:112644.|Biomed Pharmacother. 2024 Apr 17:174:116551.|BMC Med. 2023 Dec 20;21(1):507.|Cancer Cell. 2023 Jun 12;41(6):1170-1185.e12.|Cancer Commun (Lond). 2022 Jan 3.|Cancer Res. 2023 Jan 12;CAN-22-2405.|Cell Calcium. 2022 Jun;104:102571.|Cell Death Dis. 2021 Apr 1;12(4):336.|Cell Metab. 2024 Jun 18:S1550-4131(24)00189-X.|Cell Mol Immunol. 2022 Feb 22.|Cell Rep. 2021 Jul 20;36(3):109404.|Cell Rep. 2024 Mar 23;43(4):114003.|Cytotechnology. 2024 Apr 24:1-8.|EBioMedicine. 2024 Aug 6:106:105269.|Ecotoxicol Environ Saf. 2023 Dec 14:115831.|Eur J Pharmacol. 2021 Nov 9;174623.|Evid-Based Compl Alt. 2021 Jan 7.|Fish Shellfish Immunol. 2024 Mar 16:109515.|Fish Shellfish Immunol. 2024 Oct 18:109975.|Front Immunol. 05 August 2022.|Gut Microbes. 2024 Jan-Dec;16(1):2410474.|Hum Reprod. 2024 Feb 9:deae018.|Int Immunopharmacol. 2023 Sep 1;124(Pt A):110865.|Int Immunopharmacol. 2024 Sep 16;142(Pt B):113170.|Int J Biol Macromol. 2023 Jun 13;125373.|Int J Mol Sci. 2023 Aug 8, 24(16), 12557.|J Cell Mol Med. 2024 Aug;28(15):e18589.|J Ethnopharmacol. 2022 Dec 8;303:116031.|J Immunol. 2021 Mar 1;206(5):963-977.|J Immunother Cancer. 2024 Dec 9;12(12):e009910.|J Nanobiotechnology. 2024 Sep 12;22(1):556.|J Neuroimmunol. 2020 Aug 15;345:577286.|J Periodontol. 2024 Aug 29.|Microorganisms. 2023 Feb 27.|Mol Cell. 2022 May 5;S1097-2765(22)00327-6.|Mol Med. 2024 Jul 30;30(1):110.|Nat Commun. 2023 Feb 23;14(1):1020.|Oncol Rep. 2024 Feb;51(2):29.|Preprints. 2023 Mar 6.|Proc Natl Acad Sci U S A. 2022 Feb 22;119(8):e2114851119.|Protein Cell. 2021 Oct 22;1-21.|Redox Biol. 2023 Nov 10, 102959.|Reprod Fert Develop. 33(2) 108-108.|Research Square Preprint. 2023 Aug 11.|Research Square Print. 2022 Jun.|Sci Signal. 2023 Feb 28;16(774):eadd0645.|Sci Total Environ. 2021, 146523.|Sci Transl Med. 2020 Nov 25;12(571):eaaz6667.|Theranostics. 2023 May 8;13(9):2879-2895.|Vaccines. 2023 May 25, 11(6), 1026.|Immunobiology. 2024 Sep 16.|Int Immunopharmacol. 2023 Nov 16:126:111212.|OncoImmunology. 2023 Oct 12;12(1):2268257.

• Shipping Conditions:

  Blue Ice

• CAS Number:

  56092-81-0