CD14 antibody

• Background:

  Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655) . In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655) . Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135) . Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211) .

• Synonyms:

  Monocyte differentiation antigen CD14|Myeloid cell-specific leucine-rich glycoprotein|Monocyte differentiation antigen CD14, urinary form|Monocyte differentiation antigen CD14, membrane-bound form|CD14

• Gene ID:

  929

• UniProt:

  P08571

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  CD14 molecule

• Target:

  CD14

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB

• Field of Research:

  Stem Cells, Immunology, Signal Transduction, Cancer

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:200-1:2000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  50-55 kDa

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB

• Immunogen Sequence:

  20-214aa