Rat Recombinant Thioredoxin Reductase 1 (aa 3-499)

• Description:

  Rat Recombinant Thioredoxin Reductase 1 (aa 3-499)_x000D_ Catalog number: B2016937_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 5 U_x000D_ Molecular Weight or Concentration: 54.5 kDa_x000D_ Supplied as: Solution_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: -80°C_x000D_ Keywords: NADPH-dependent Thioredoxin Reductase, TrxR1, Txnrd1_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Cheng P, Liu H, Li Y, Pi P, Jiang Y, Zang S, Li X, Fu A, Ren X, Xu J, Holmgren A, Lu J. Inhibition of thioredoxin reductase 1 correlates with platinum-based chemotherapeutic induced tissue injury Biochem Pharmacol. 2020 May;175:113873._x000D_ 2: Wang L, Yang Z, Fu J, Yin H, Xiong K, Tan Q, Jin H, Li J, Wang T, Tang W, Yin J, Cai G, Liu M, Kehr S, Becker K, Zeng H. Ethaselen: a potent mammalian thioredoxin reductase 1 inhibitor and novel organoselenium anticancer agent Free Radic Biol Med. 2012 Mar 1;52(5):898-908._x000D_ 3: Dagnell M, Pace PE, Cheng Q, Frijhoff J, Östman A, Arnér ESJ, Hampton MB, Winterbourn CC. Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H(2)O(2) exposure J Biol Chem. 2017 Sep 1;292(35):14371-14380._x000D_ 4: Rengby O, Cheng Q, Vahter M, Jörnvall H, Arnér ES. Highly active dimeric and low-activity tetrameric forms of selenium-containing rat thioredoxin reductase 1 Free Radic Biol Med. 2009 Apr 1;46(7):893-904._x000D_ 5: Cheng Q, Sandalova T, Lindqvist Y, Arnér ES. Crystal structure and catalysis of the selenoprotein thioredoxin reductase 1 J Biol Chem. 2009 Feb 6;284(6):3998-4008._x000D_ 6: Engelman R, Ziv T, Arnér ESJ, Benhar M. Inhibitory nitrosylation of mammalian thioredoxin reductase 1: Molecular characterization and evidence for its functional role in cellular nitroso-redox imbalance Free Radic Biol Med. 2016 Aug;97:375-385._x000D_ 7: Peng X, Zhang MQ, Conserva F, Hosny G, Selivanova G, Bykov VJ, Arnér ES, Wiman KG. APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase Cell Death Dis. 2013 Oct 24;4(10):e881._x000D_ 8: Gencheva R, Cheng Q, Arnér ESJ. Efficient selenocysteine-dependent reduction of toxoflavin by mammalian thioredoxin reductase Biochim Biophys Acta Gen Subj. 2018 Nov;1862(11):2511-2517._x000D_ 9: Jovanović M, Zhukovsky D, Podolski-Renić A, Domračeva I, Žalubovskis R, Senćanski M, GliÅ¡ić S, Sharoyko V, Tennikova T, Dar'in D, PeÅ¡ić M, Krasavin M. Novel electrophilic amides amenable by the Ugi reaction perturb thioredoxin system via thioredoxin reductase 1 (TrxR1) inhibition: Identification of DVD-445 as a new lead compound for anticancer therapy Eur J Med Chem. 2019 Nov 1;181:111580._x000D_ 10: Pickering IJ, Cheng Q, Rengifo EM, Nehzati S, Dolgova NV, Kroll T, Sokaras D, George GN, Arnér ESJ. Direct Observation of Methylmercury and Auranofin Binding to Selenocysteine in Thioredoxin Reductase Inorg Chem. 2020 Mar 2;59(5):2711-2718. _x000D_ _x000D_ Products Related to Rat Recombinant Thioredoxin Reductase 1 (aa 3-499) can be found at Proteins

• Short Description:

  Catalog Number: B2016937 (5 U)_x000D_ Rat Recombinant Thioredoxin Reductase 1 (aa 3-499) is a high quality enzyme that plays a key role in regulating cellular redox balance by catalyzing the reduction of thioredoxin, a small redox protein involved in various cellular processes. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3