Cosdosiran

• Description :

  Cosdosiran is a chemically modified siRNA designed to temporarily inhibit expression of the caspase 2 protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.

• CAS Number :

  [1834560-88-1]

• Product Name Alternative :

  QPI-1007

• UNSPSC :

  12352208

• Target :

  Caspase; Small Interfering RNA (siRNA)

• Type :

  Oligonucleotides

• Related Pathways :

  Apoptosis; Epigenetics

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/cosdosiran.html

• Purity :

  98.48

• Solubility :

  10 mM in H2O

• Smiles :

  [Cosdosiran]

• References & Citations :

  [1]Solano EC, Kornbrust DJ, Beaudry A, Foy JW, Schneider DJ, Thompson JD. Toxicological and pharmacokinetic properties of QPI-1007, a chemically modified synthetic siRNA targeting caspase 2 mRNA, following intravitreal injection. Nucleic Acid Ther. 2014;24 (4) :258-266. doi:10.1089/nat.2014.0489

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Oligonucleotides

• Clinical Information :

  Phase 3