L-Azidohomoalanine-1,2,3,4-13C4 (hydrochloride)

L-Azidohomoalanine-1,2,3,4-13C4 (hydrochloride)

• CAS Number: 2483829-89-4
• UNSPSC Description: L-Azidohomoalanine-1,2,3,4-13C4 (hydrochloride) is the 13C- and 15N-labeled L-Azidohomoalanine hydrochloride. L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. L-Azidohomoalanine-1,2,3,4-13C4 (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
• Target Antigen: Isotope-Labeled Compounds; PROTAC Linkers
• Type: Isotope-Labeled Compounds
• Related Pathways: Others;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/l-azidohomoalanine-1-2-3-4-13c4-hydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: [N-]=[N+]=[15N][13CH2][13CH2][13C@H]([15NH2])[13C](O)=O.Cl
• Molecular Weight: 186.55
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported