Human Fc gamma RIIB/C (CD32b/c) Protein, Strep Tag (MALS & SPR verified)

Human Fc gamma RIIB/C (CD32b/c) Protein, Strep Tag (MALS & SPR verified)

• Background: Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.
• Description: Human CD32b/c Protein, Strep Tag (CDB-H5284) is expressed from human 293 cells (HEK293). It contains AA Ala 46 - Pro 217 (Accession # P31994-1).
• Specifications: This protein carries a twin strep tag at the C-terminus. The protein has a calculated MW of 22.7 kDa. The protein migrates as 30-34 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expression Region: Ala 46 - Pro 217
• Host: HEK 293
• Target: Fc gamma RIIB/C / CD32b/c
• Conjugation: Unconjugated
• Tag: C-Twin-Strep
• Source: Human
• Stability: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Endotoxin: 1.0 EU per μg
• Purity: 95%
• Format: Powder
• Buffer: PBS, pH7.4
• Additives: Trehalose
• Molecular Weight: 22.7 kDa
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C