SCH772984

CAT: 0804-HY-50846-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-50846-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
SCH772984 is a highly selective and ATP-competitive ERK inhibitor, with IC50s of 4 and 1 nM for ERK1 and ERK2, respectively. SCH772984 has antitumor activity in MAPK inhibitor-na ve and MAPK inhibitor-resistant cells containing BRAF or RAS mutations[1].
CAS Number
[942183-80-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ERK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SCH772984.html
Purity
99.52
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
O=C([C@H](CC1)CN1CC(N(CC2)CCN2C(C=C3)=CC=C3C4=NC=CC=N4)=O)NC5=CC6=C(C=C5)NN=C6C7=CC=NC=C7
Molecular Formula
C33H33N9O2
Molecular Weight
587.67
Precautions
H302, H315, H319, H335
References & Citations
[1]Morris EJ, et al. Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. Cancer Discov. 2013 Jul;3 (7) :742-50.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK1; ERK2

Related Products

CatalogName

Alternative Products

CatalogName
465944-01SCH772984
MBS5757804SCH772984 TFA
A12824-5SCH772984 5mg
A12824-100SCH772984 100mg
A12824-200SCH772984 200mg
B5866-10SCH772984 HCl

Popular Products