TC-G-1008

TC-G-1008

• CAS Number: 1621175-65-2
• UNSPSC Description: TC-G-1008 (GPR39-C3) is a potent and orally available GPR39 agonist with EC50 values of 0.4 and 0.8 nM for rat and human receptors respectively.
• Target Antigen: GHSR
• Type: Reference compound
• Related Pathways: GPCR/G Protein
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease; Endocrinology
• Assay Protocol: https://www.medchemexpress.com/TC-G-1008.html
• Purity: 99.61
• Solubility: DMSO : ≥ 100 mg/mL
• Smiles: CS(=O)(NC1=CC=C(CNC2=NC(NC)=NC(C3=NC=CC=C3)=C2)C(Cl)=C1)=O
• Molecular Weight: 418.90
• References & Citations: [1]Peukert S, et al. Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists. ACS Med Chem Lett. 2014 Aug 4;5(10):1114-8.|[2]Shimizu Y, et al. Rho kinase-dependent desensitization of GPR39; a unique mechanism of GPCR downregulation. Biochem Pharmacol. 2017 Sep 15;140:105-114.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported