Anti-TTF-1 / NKX2.1 (Thyroid & Lung Epithelial Marker) (NX2.1/1855R)

• Description:

  This antibody recognizes a protein of 40 kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates. Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

• Synonyms:

  BCH; Benign chorea; BHC; Homeobox protein Nkx2.1; NK2 homeobox 1; NKX2.1; NKX2A; TEBP; Thyroid nuclear factor-1; Thyroid specific enhancer binding protein; Thyroid transcription factor-1 (TTF-1); Tin man; TITF1; TTF-1

• CAS Number:

  9007-83-4

• UNSPSC:

  41116161

• UNSPSC Description:

  Primary and secondary antibodies for multiple methodology immunostaining detection application

• Gene Name:

  NKX2-1

• Gene ID:

  7080

• NCBI Gene ID:

  94367

• UniProt:

  P43699

• Cellular Locus:

  Nucleus

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant human full-length TTF-1 protein

• Target Antigen:

  NKX2.1 | TTF-1

• Clonality:

  Recombinant Monoclonal

• Isotype:

  IgG

• Clone:

  NX2.1/1855R

• Conjugation:

  Purified, with BSA

• Disease:

  Tumor

• Source:

  Animal

• Applications:

  IHC, FFPE (verified)

• Validated Applications:

  IHC, FFPE

• Field of Research:

  Cancer, Transcription factors

• Positive Control:

  MAD109, MLE-15, H441-4, or H345 cells. Normal thyroid or lung.

• Concentration:

  0.2 mg/mL

• Buffer:

  PBS, 0.05% BSA, 0.05% azide

• Molecular Weight:

  40 kDa

• Shipping Conditions:

  Room temperature

• Storage Conditions:

  4°C; Stable at room temperature or 37°C (98°F) for 7 days.

• Shelf Life:

  2 years