Anti-Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16 (CDH16/1532R)

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Anti-Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16 (CDH16/1532R)

CAT:

37-BNUB1532-100

Size:

100 µL

Price:

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Anti-Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16 (CDH16/1532R)

Description: This MAb recognizes a protein of 130 kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels. Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Synonyms: Cadherin-16 (CDH16); Kidney-specific cadherin; Ksp-cadherin antibody
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: CDH16
Gene ID: 1014
NCBI Gene ID: 513660
UniProt: O75309
Cellular Locus: Plasma membrane
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Recombinant human full-length CDH16 protein
Target Antigen: CDH16 | Ksp-Cadherin
Clonality: Recombinant Monoclonal
Isotype: IgG κ
Clone: CDH16/1532R
Conjugation: Purified, with BSA
Disease: Tumor
Source: Animal
Applications: Flow (verified) | IHC, FFPE (verified) | WB (verified)
Validated Applications: FC, IHC, FFPE, WB
Field of Research: Cell adhesion
Positive Control: Normal kidney or renal cell carcinoma
Concentration: 0.2 mg/mL
Buffer: PBS, 0.05% BSA, 0.05% azide
Molecular Weight: 130 kDa
Additionnal Information: Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Immunofluorescence: 1-2 ug/mL|Immunohistology (formalin): 0.5-1 ug/mL|Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris with 1 mM EDTA Buffer pH 9.0 for 10-20 min followed by cooling at RT for 20 min|Flow Cytometry 0.5-1 ug/million cells/0.1 mL|Optimal dilution for a specific application should be determined by user
Shipping Conditions: Room temperature
Storage Conditions: 4°C; Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: 2 years

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BNUB1633-100	Anti-Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16
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BNC941633-100	Anti-Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16, CF594 conjugate
BNUB1532-100	Anti-Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16 (CDH16/1532R)
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BNUM1532-50	Anti-Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16 (CDH16/1532R)