Loxapine

• Description:

  Loxapine is an orally active dopamine inhibitor, 5-HT receptor antagonist and also a dibenzoxazepine anti-psychotic agent[1][4].

• UNSPSC:

  12352005

• Hazard Statement:

  H301

• Target:

  5-HT Receptor; Bacterial; Dopamine Receptor

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Loxapine.html

• Concentration:

  10mM

• Purity:

  99.93

• Solubility:

  DMSO : ≥ 33.33 mg/mL

• Smiles:

  CN1CCN(C2=NC3=CC=CC=C3OC4=CC=C(Cl)C=C24)CC1

• Molecular Formula:

  C18H18ClN3O

• Molecular Weight:

  327.81

• Precautions:

  H301

• References & Citations:

  [1]Singh AN, et al. A neurochemical basis for the antipsychotic activity of loxapine: interactions with dopamine D1, D2, D4 and serotonin 5-HT2 receptor subtypes. J Psychiatry Neurosci. 1996 Jan;21 (1) :29-35.|[2]Labuzek K, et al. Chlorpromazine and loxapine reduce interleukin-1beta and interleukin-2 release by rat mixed glial and microglial cell cultures. Eur Neuropsychopharmacol. 2005 Jan;15 (1) :23-30.|[3]Lee T, et al. Loxapine and clozapine decrease serotonin (S2) but do not elevate dopamine (D2) receptor numbers in the rat brain. Psychiatry Res. 1984 Aug;12 (4) :277-85.|[4]Kalkman HO, et al. Clozapine inhibits catalepsy induced by olanzapine and loxapine, but prolongs catalepsy induced by SCH 23390 in rats. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355 (3) :361-4.|[5]Keating GM. Loxapine inhalation powder: a review of its use in the acute treatment of agitation in patients with bipolar disorder or schizophrenia. CNS Drugs. 2013 Jun;27 (6) :479-89.|[6]Yang CY, et al. Loxapine, an antipsychotic drug, suppresses intracellular multiple-antibiotic-resistant Salmonella enterica serovar Typhimurium in macrophages. J Microbiol Immunol Infect. 2019 Aug;52 (4) :638-647.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  D1 Receptor; D2 Receptor; D4 Receptor; α-1 microglobulin

• CAS Number:

  [1977-10-2]