Mouse/Rat Leptin Recombinant Rabbit Monoclonal Antibody [PSH08-95] - BSA and Azide free (Detector)

Mouse/Rat Leptin Recombinant Rabbit Monoclonal Antibody [PSH08-95] - BSA and Azide free (Detector)

• Description: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1.
• Product Name Alternative: FLJ94114 antibody LEP antibody LEP_HUMAN antibody LEPD antibody Leptin (murine obesity homolog) antibody Leptin (obesity homolog, mouse) antibody Leptin antibody Leptin Murine Obesity Homolog antibody Leptin Precursor Obesity Factor antibody OB antibody Obese protein antibody Obese, mouse, homolog of antibody Obesity antibody Obesity factor antibody Obesity homolog mouse antibody Obesity Murine Homolog Leptin antibody OBS antibody OTTHUMP00000212285 antibody
• Abbreviation: Leptin Obesity factor Lep Ob
• CAS Number: 9000-83-3
• Swiss Prot: P41160 Mosue, P50596 Rat
• Cellular Locus: Secreted.
• Host: Rabbit
• Species Reactivity: Mouse, Rat
• Immunogen: Recombinant protein within Mouse Leptin aa 22-167.
• Isotype: IgG
• Clone: PSH08-95
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: ELISA (Det)
• Positive Control: Recombinant Mouse Leptin protein (HA210898).
• Concentration: 1 mg/mL
• Dilution: ELISA (Det): Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PSH08-94] to Mouse/Rat Leptin antibody (Capture) (HA723046) and recombinant Mouse/Rat Leptin protein (HA210898) as the standard. The reference range value is 31-4,000 pg/ml.
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4).
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes