Valecobulin
CAT:
804-HY-13598-01
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Valecobulin
- CAS Number: 1188371-47-2
- UNSPSC Description: Valecobulin (CKD516) is a valine proagent of (S516) and a vascular disrupting agent (VDA). Valecobulin is a potent β-tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors[1][2].
- Target Antigen: Microtubule/Tubulin
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;Cytoskeleton
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/Valecobulin.html
- Smiles: CC(C)[C@H](N)C(NC1=NC(C2=CC=C(C(C3=CC(OC)=C(OC)C(OC)=C3)=O)C(N4N=CN=C4)=C2)=CS1)=O
- Molecular Weight: 536.60
- References & Citations: [1]Lee J, et al. Identification of CKD-516: a potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors. J Med Chem. 2010 Sep 9;53(17):6337-54.|[2]Joo I, et al. Intravoxel incoherent motion diffusion-weighted MR imaging for monitoring the therapeutic efficacy of the vascular disrupting agent CKD-516 in rabbit VX2 liver tumors. Radiology. 2014 Aug;272(2):417-26.
- Shipping Conditions: Room Temperature