M1069 (free base)

M1069 (free base)

• CAS Number: 2459881-03-7
• UNSPSC Description: M1069 (free base) is a selective and orall active, dual A2A/A2B adenosine receptor antagonist with a selectivity of >100 fold against the A1 and A3 receptors. M1069 (free base) counteracts immune-suppressive mechanisms of adenosine, and exhibits anti-tumor activity[1][2][3].
• Target Antigen: Adenosine Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/m1069-free-base.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: COC1=C2C(SC(NC(N3C[C@]4(CCCOC4)CC3)=O)=N2)=C(C5=CCOCC5)C=N1
• Molecular Weight: 430.52
• References & Citations: [1]Rinat Zaynagetdinov, et al. Abstract 3499: M1069 as dual A2A/A2B adenosine receptor antagonist counteracts immune-suppressive mechanisms of adenosine and reduces tumor growth in vivo. Cancer Res (2022) 82 (12_Supplement):3499.|[2]Tanzer Eva-Maria, et al. Preparation of thiazolopyridine derivatives as adenosine receptor antagonists: World Intellectual Property Organization, WO2020152132[P]. 2020-07-30.|[3]Lillian L Siu, et al. Abstract CT240: A first-in-human study of the dual A2A/A2B adenosine receptor antagonist M1069 in patients with advanced solid tumors. Cancer Res (2022) 82 (12_Supplement):CT240.
• Shipping Conditions: Room Temperature
• Clinical Information: Phase 1