Homo-PROTAC pVHL30 degrader 1

Homo-PROTAC pVHL30 degrader 1

• CAS Number: 2244684-49-7
• UNSPSC Description: Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC[1], consists of two ligands of von Hippel-Lindau.
• Target Antigen: PROTACs
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/Homo-PROTAC_pVHL30_degrader_1.html
• Purity: 99.40
• Solubility: DMSO : ≥ 150 mg/mL|H2O : 25 mg/mL (ultrasonic)
• Smiles: CC1=C(C2=CC=C(CNC([C@@H]3C[C@@]([H])(O)CN3C([C@H](C(C)(C)C)NC(COCCOCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@]([H])(O)C4)=O)=O)=O)=O)=O)C=C2)SC=N1
• Molecular Weight: 1179.45
• References & Citations: [1]Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017 Oct 10;8(1):830.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, stored under nitrogen)
• Clinical Information: No Development Reported