L321

• Description :

  4-Methylphenoxyacetic acid-Oxindole-CF3 is the E3 ligase ligand part of L134 (HY-169358) . 4-Methylphenoxyacetic acid-Oxindole-CF3 can be utilized in PROTAC synthesis[1].

• UNSPSC :

  12352005

• Target :

  Ligands for E3 Ligase

• Type :

  Reference compound

• Related Pathways :

  PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/l321.html

• Smiles :

  CC1=CC=C(C(/C=C2C(NC3=C\2C=CC(C(F)(F)F)=C3)=O)=C1)OCC(OC(C)(C)C)=O

• Molecular Formula :

  C23H22F3NO4

• Molecular Weight :

  433.42

• References & Citations :

  [1]Zhao M, et al. Design, Synthesis, and Activity Evaluation of BRD4 PROTAC Based on Alkenyl Oxindole-DCAF11 Pair. J Med Chem. 2024 Nov 14;67 (21) :19428-19447.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Cereblon