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Bromopride

CAT: 0804-HY-B1164-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1164-01Size:5 mg
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Description
Bromopride is a selective, irreversible, competitive, and orally effective dopamine D2 receptor antagonist. Bromopride can pass through the blood-brain barrier, inhibit the vomiting center, and enhance gastrointestinal motility, exerting antiemetic and gastrointestinal motility effects. Bromopride antagonizes dopamine-mediated vomiting reflexes and promotes gastrointestinal smooth muscle contraction, and has no adverse effects on abdominal wall healing in rats with postoperative abdominal infection. Bromopride can be used for the study of digestive system diseases (such as gastric hypomotility, nausea and vomiting) [1][2].
CAS Number
4093-35-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Bromopride.html
Purity
99.53
Solubility
DMSO : 170 mg/mL (ultrasonic)
Smiles
O=C(NCCN(CC)CC)C1=CC(Br)=C(N)C=C1OC
Molecular Formula
C14H22BrN3O2
Molecular Weight
344.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Huebner EA, et al. Diltiazem Promotes Regenerative Axon Growth. Mol Neurobiol. 2019 Jun;56 (6) :3948-3957.|[2]Dunne CE, et al. Metabolism of bromopride in mouse, rat, rabbit, dog, monkey, and human hepatocytes. Drug Metab Pharmacokinet. 2013;28 (6) :453-61.|[3]Oliveira MV, et al. Effects of bromopride on abdominal wall healing with induced peritoneal sepsis after segmental colectomy and colonic anastomosis in rats. Acta Cir Bras. 2011 Dec;26 (6) :433-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
D2 Receptor

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