(-)-Sotalol

• Product Name Alternative:

  (R)-Sotalol

• UNSPSC Description:

  (-)-Sotalol ((R)-Sotalol) is the R-isomer of Sotalol. (-)-Sotalol is a hERG inhibitor, with a Kd of 0.60 μM. (-)-Sotalol can be used for the research of cardiac arrhythmias[1].

• Target Antigen:

  Potassium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/minus-sotalol.html

• Purity:

  98.73

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CS(=O)(NC1=CC=C(C=C1)[C@H](CNC(C)C)O)=O

• Molecular Weight:

  272.36

• References & Citations:

  [1]DeMarco KR, et, al. Molecular determinants of pro-arrhythmia proclivity of d- and l-sotalol via a multi-scale modeling pipeline. J Mol Cell Cardiol. 2021 Sep;158:163-177.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  30236-31-8