Aprepitant (Standard)

CAT: 0804-HY-10052R-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-10052R-01Size:5 mg
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Description
Aprepitant (Standard) is the analytical standard of Aprepitant. This product is intended for research and analytical applications. Aprepitant (MK-0869) is a selective and high-affinity neurokinin 1 receptor antagonist with a Kd of 86 pM.
CAS Number
[170729-80-3]
Product Name Alternative
MK-0869 (Standard) ; MK-869 (Standard) ; L-754030 (Standard)
UNSPSC
12352005
Hazard Statement
H319-H351
Target
Antibiotic; Bacterial; HIV; Neurokinin Receptor; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Neurological Disease; Endocrinology; Cancer
Assay Protocol
https://www.medchemexpress.com/aprepitant-standard.html
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1NC(CN2[C@H]([C@@H](O[C@@H](C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C)OCC2)C4=CC=C(F)C=C4)=NN1
Molecular Formula
C23H21F7N4O3
Molecular Weight
534.43
Precautions
P264-P280-P305+P351+P338-P405-P501
References & Citations
[1]Martinez AN, et al. Aprepitant limits in vivo neuroinflammatory responses in a rhesus model of Lyme neuroborreliosis. J Neuroinflammation. 2017 Feb 15;14 (1) :37.|[2]Bayati S, et al. Inhibition of tachykinin NK1 receptor using aprepitant induces apoptotic cell death and G1 arrest through Akt/p53 axis in pre-B acute lymphoblastic leukemia cells. Eur J Pharmacol. 2016 Nov 15;791:274-283.|[3]Mannangatti P, et al. Differential effects of aprepitant, a clinically used neurokinin-1 receptor antagonist on the expression of conditioned psychostimulant versus opioid reward. Psychopharmacology (Berl) . 2017 Feb;234 (4) :695-705.|[4]Barrett JS, et al. Pharmacologic rationale for the NK1R antagonist, aprepitant as adjunctive therapy in HIV. J Transl Med. 2016 May 26;14 (1) :148.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
Launched

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