20(S)-Ginsenoside Rg3

20(S)-Ginsenoside Rg3

• CAS Number: 14197-60-5
• UNSPSC Description: 20(S)-Ginsenoside Rg3 is the main component of Panax ginseng C. A. Meyer. Ginsenoside Rg3 inhibits Na+ and hKv1.4 channel with IC50s of 32.2±4.5 and 32.6±2.2 μM, respectively. 20(S)-Ginsenoside Rg3 also inhibits Aβ levels, NF-κB activity, and COX-2 expression.
• Target Antigen: Amyloid-β; COX; Endogenous Metabolite; NF-κB; Potassium Channel; Sodium Channel
• Type: Natural Products
• Related Pathways: Immunology/Inflammation;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling;NF-κB
• Applications: Cancer-programmed cell death
• Field of Research: Cancer; Inflammation/Immunology; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/Ginsenoside-Rg3.html
• Purity: 99.94
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O[C@@H]([C@@H]([C@@H](CO)O1)O)[C@@H](O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)[C@@H]1O[C@H]3CC[C@]4(C)[C@@]5([H])C[C@@H](O)[C@]6([H])[C@@H](C(C)(O)CC/C=C(C)\C)CC[C@](C)6[C@@](C)5CCC4C3(C)C
• Molecular Weight: 785.01
• References & Citations: [1]Kim JH, et al. A role for the carbohydrate portion of ginsenoside Rg3 in Na⁺ channel inhibition. Mol Cells. 2005 Feb 28;19(1):137-42.|[2]Lee JH, et al. Ginsenoside Rg3 inhibits human Kv1.4 channel currents by interacting with the Lys531 residue. Mol Pharmacol. 2008 Mar;73(3):619-26.|[3]Lee IS, et al. Anti-Inflammatory Effects of Ginsenoside Rg3 via NF-κB Pathway in A549 Cells and Human Asthmatic Lung Tissue. J Immunol Res. 2016;2016:7521601.|[4]Kang MS, et al. Modulation of lipid kinase PI4KIIα activity and lipid raft association of presenilin 1 underlies γ-secretase inhibition by ginsenoside (20S)-Rg3. J Biol Chem. 2013 Jul 19;288(29):20868-82.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Launched