NAcM-OPT (hydrochloride)

• CAS Number:

  2416146-10-4

• UNSPSC Description:

  NAcM-OPT (hydrochloride) is a protein interaction inhibitor. NAcM-OPT (hydrochloride) can disrupt the interaction between DCN1 and UBC12, with an IC50 value of 80 nM. NAcM-OPT (hydrochloride) can protect keratinocytes from H2O2-induced cell damage by promoting autophagy[1][2].

• Target Antigen:

  Autophagy

• Type:

  Reference compound

• Related Pathways:

  Autophagy

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/nacm-opt-hydrochloride.html

• Smiles:

  O=C(NC1=CC=C(Cl)C(Cl)=C1)N(C2CCN(CCCC)CC2)CC3=CC=CC=C3.Cl

• Molecular Weight:

  470.86

• References & Citations:

  [1]Fang Y, et al. Targeting the DCN1-UBC12 protein-protein interaction: novel approaches and future directions. Future Med Chem. 2019 Nov;11(22):2869-2871.|[2]Xiong R, et al. NAcM-OPT protects keratinocytes from H2O2-induced cell damage by promoting autophagy. Ann N Y Acad Sci. 2024 Jul;1537(1):155-167.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported