Riluzole

• UNSPSC Description:

  Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM.

• Target Antigen:

  GABA Receptor; Sodium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/riluzole.html

• Purity:

  99.80

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)|H2O : 1 mg/mL (ultrasonic;adjust pH to 3 with HCl)

• Smiles:

  NC1=NC2=CC=C(OC(F)(F)F)C=C2S1

• Molecular Weight:

  234.202

• References & Citations:

  [1]He Y, et al. Neuroprotective agent riluzole potentiates postsynaptic GABA(A) receptor function. Neuropharmacology. 2002 Feb;42(2):199-209.|[2]Thompson JM, et al. Small-conductance calcium-activated potassium (SK) channels in the amygdala mediate pain-inhibiting effects of clinically available riluzole in a rat model of arthritis pain. Mol Pain. 2015 Aug 28;11:51.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Launched

• CAS Number:

  1744-22-5