SNCA Polyclonal Antibody

CAT: 0763-D-AB-10173L-01Size: 25 µLDry Ice: NoHazardous: No
CAT#:0763-D-AB-10173L-01Size:25 µL
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Background
Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release.Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores.Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis.Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5.
Abbreviation
SNCA
UniProt
P37840
Host
Rabbit
Reactivity
Human; mouse; Rat
Immunogen
Recombinant Human SNCA protein expressed by E.coli
Target
SNCA; NACP; PARK1; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Cancer; Neuroscience
Purification
Antigen Affinity Purification
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000
Buffer
PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
14 kDa
Observed Molecular Weight
16 kDa
Isotype
IgG
Product Datasheet
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