Vidarabine

• Description:

  Vidarabine (Ara-A) an antiviral agent which is active against herpes simplex and varicella zoster viruses[1][2]. Vidarabine has IC50s of 9.3 μg/ml for HSV-1 and 11.3 μg/ml for HSV-2[2]. Vidarabine also has anti-orthopoxvirus activity[3].

• Product Name Alternative:

  Ara-A; Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine

• UNSPSC:

  12352005

• Hazard Statement:

  H361

• Target:

  Antibiotic; HSV; Nucleoside Antimetabolite/Analog; Orthopoxvirus

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Cell Cycle/DNA Damage

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/Vidarabine.html

• Concentration:

  10mM

• Purity:

  99.36

• Solubility:

  DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

• Smiles:

  OC[C@@H]1[C@@H](O)[C@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O1

• Molecular Formula:

  C10H13N5O4

• Molecular Weight:

  267.25

• Precautions:

  H361

• References & Citations:

  [1]Whitley, R., et al., Vidarabine: a preliminary review of its pharmacological properties and therapeutic use. Drugs, 1980. 20 (4) : p. 267-82.|[2]Suzuki M, et al. Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 2006;72 (2) :157-161.|[3]Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57 (1-2) :41-52.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• Isoform:

  HSV-1; HSV-2

• CAS Number:

  [5536-17-4]