1-Alaninechlamydocin

1-Alaninechlamydocin

• CAS Number: 141446-96-0
• UNSPSC Description: 1-Alaninechlamydocin, a cyclic tetrapeptide, is a potent HDAC inhibitor (IC50=6.4 nM). 1-Alaninechlamydocin induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells[1].
• Target Antigen: Apoptosis; HDAC
• Type: Peptides
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/1-alaninechlamydocin.html
• Solubility: 10 mM in DMSO
• Smiles: O=C([C@@H](NC([C@@H]1C)=O)CC2=CC=CC=C2)N(CCC3)[C@@]3([H])C(N[C@H](C(N1)=O)CCCCCC([C@@H]4CO4)=O)=O
• Molecular Weight: 512.60
• References & Citations: [1]Du L, et al. A potent HDAC inhibitor, 1-alaninechlamydocin, from a Tolypocladium sp. induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells. J Nat Prod. 2014;77(7):1753-1757.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported