5J-4

CAT: 0804-HY-110216-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-110216-01Size:5 mg
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AVAILABILITY: InStock
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Description
5J-4 is a potent CRAC inhibitor. 5J-4 decreases the numbers of infiltrated mononuclear cell into the CNS, and significantly decreases the population of infiltrated CD4+ population. 5J-4 reduces the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in mouse model of inflammation[1].
CAS Number
[827001-82-1]
UNSPSC
12352005
Target
CRAC Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/5j-4.html
Purity
95
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CO1)NC(NC2=CC=CC3=C2C=CC(O)=C3)=S
Molecular Formula
C16H12N2O3S
Molecular Weight
312.35
References & Citations
[1]Kim KD, et al. Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation. J Immunol. 2014 Jan 1;192 (1) :110-22.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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