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5-OMe-UDP

CAT: 0804-HY-108663Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-108663Size:1 Each
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Description
5-OMe-UDP (5-methoxyuridine 5'-trihydrogen diphosphate) is a P2Y6 receptor agonist (EC50=0.08 μM) . 5-OMe-UDP activates the P2Y6 receptor by binding to it, which triggers signaling pathways within the cell. This activation can lead to an increase in intracellular calcium ion concentration, which in turn regulates cellular function. The methoxy groups of 5-OMe-UDP provide additional activity and selectivity, contributing to the binding of 5-OMe-UDP to the P2Y6 receptor. 5-OMe-UDP can be used to study diseases related to P2Y6 receptor function, such as diabetes, inflammatory bowel disease, Alzheimer's disease, etc[1].
CAS Number
1207530-98-0
Product Name Alternative
5-Methoxyuridine 5'- (trihydrogen diphosphate)
UNSPSC
12352005
Target
P2Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/5-ome-udp.html
Smiles
O=C(N1)N([C@@H]2O[C@H](COP(O)(OP(O)(O)=O)=O)[C@@H](O)[C@H]2O)C=C(OC)C1=O
Molecular Formula
C10H16N2O13P2
Molecular Weight
434.19
References & Citations
[1]Ginsburg-Shmuel T, et al. UDP made a highly promising stable, potent, and selective P2Y6-receptor agonist upon introduction of a boranophosphate moiety[J]. Bioorganic & medicinal chemistry, 2012, 20 (18) : 5483-5495.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2Y6 Receptor

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