(S)-Gossypol (acetic acid)
CAT:
804-HY-15464D-05
Size:
10 mM / 1 mL
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
(S)-Gossypol (acetic acid)
- CAS Number: 1189561-66-7
- UNSPSC Description: (S)-Gossypol is the isomer of a natural product Gossypol. (S)-Gossypol binds to the BH3-binding groove of Bcl-xL and Bcl-2 proteins with high affinity.
- Target Antigen: Bcl-2 Family
- Type: Reference compound
- Related Pathways: Apoptosis
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/_S_-Gossypol-acetic-acid.html
- Solubility: DMSO : 50 mg/mL (ultrasonic)
- Smiles: OC1=C2C(C=O)=C(O)C(O)=C(C(C)C)C2=CC(C)=[C@@]1[C@@]3=C(C)C=C4C(C(C)C)=C(O)C(O)=C(C=O)C4=C3O.CC(O)=O
- Molecular Weight: 578.61
- References & Citations: [1]Oliver CL, et al. In vitro effects of the BH3 mimetic, (-)-Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10(22):7757-63.Patent. US20220162561A1.|Cancer Lett. 2019 Oct 1;461:31-43. |Clin Transl Med. 2021 Jun;11(6):e467.|Patent. US20220162561A1.|Microb Pathog. 2024 Sep 21:106960.|Transbound Emerg Dis. 2023 Nov 11.|Nat Commun. 2023 Jun 10;14(1):3445.
- Shipping Conditions: Blue Ice
- Clinical Information: Phase 3