Quinfamide

CAT: 0804-HY-119826-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-119826-01Size:5 mg
Selected
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Quinfamide (WIN-40014) is an orally active class of dichloroacetyl derivative with significant anti-intestinal protozoan, particularly mmoeba histolytica activity. Quinfamide exhibits antiamoebic activity under solvent-free conditions with an IC50 of 28.15 μg/mL in a suspension condition. Quinfamide particles are actively engulfed by the amoebas, then cells are affected, and finally, amoebas are killed and lysed, and this process directly relies on the physical intake of the drug particles. Quinfamide can be used in the research of tropical parasitic infections such as amoebiasis and helminthiasis[1][2][3].
CAS Number
[62265-68-3]
Product Name Alternative
WIN-40014
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/quinfamide.html
Purity
99.69
Solubility
DMSO : ≥ 125 mg/mL
Smiles
O=C(OC1=CC2=C(C=C1)N(CCC2)C(C(Cl)Cl)=O)C3=CC=CO3
Molecular Formula
C16H13Cl2NO4
Molecular Weight
354.18
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Slighter RG, et al. Activity of quinfamide against natural infections of Entamoeba criceti in hamsters: a new potent agent for intestinal amoebiasis. Parasitology. 1980 Aug;81 (1) :157-68.|[2]Anaya-Velázquez F, Morales-Fuentes L. Phagocytosis of quinfamide particles by Entamoeba histolytica. Arch Med Res. 2000 Jul-Aug;31 (4 Suppl) :S10-1. |[3]Itzcoatl Aquino, et al. In vivo anticoccidial activity of quinfamide in broilers: a preliminary report. 2016 Mar
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 4
Isoform
Amebae

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