BPN-15606

• Description :

  BPN-15606 is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50 values of 7 nM and 17nM, respectively. BPN-15606 lowers Aβ42 and Aβ40 levels in the central nervous system of rats and mice. BPN-15606 has acceptable PK/PD properties, including bioavailability, half-life, and clearance[1].

• Product Name Alternative :

  ABBV-075

• UNSPSC :

  12352005

• Target :

  γ-secretase

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling; Stem Cell/Wnt

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/bpn-15606.html

• Purity :

  99.96

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC1=CC(C2=NC(OC)=C(N3C=C(C)N=C3)C=C2)=NN=C1N[C@H](C4=CC=C(F)C=C4)C

• Molecular Formula :

  C23H23FN6O

• Molecular Weight :

  418.47

• References & Citations :

  [1]Wagner SL, et al. Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606. J Pharmacol Exp Ther. 2017 Jul;362 (1) :31-44.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1914989-49-3]